The aim of this study was to synthesize evidence from randomized controlled trials (RCTs) comparing nonoperative versus surgical management of uncomplicated acute appendicitis in adult patients. Addressing patients' expectations via a shared decision-making process is a crucial step in optimizing nonoperative outcomes.Ībstract = "BACKGROUND: Acute appendicitis continues to constitute a diagnostic and therapeutic challenge. CONCLUSIONS: Conservative management of uncomplicated appendicitis in adults warrants further study. No difference was found between the two treatment modalities in terms of perforated appendicitis rates (RR, 0.52 95% CI, 0.14-1.92), length of hospital stay (weighted mean difference, 0.20 95% CI,-0.16 to 0.56), duration of pain (WMD, 0.22 95% CI,-5.30 to-5.73), and sick leave (WMD,-2 95% CI,-5.2 to 1.1). Overall complications were significantly higher in the surgery group (166/703 ) compared with the antibiotics group (56/727 ) (RR, 0.32 95% CI, 0.24-0.43 p < 0.001). Treatment efficacy at 1-year follow-up was significantly lower (63.8%) for antibiotics compared with the surgery group (93%) (risk ratio, 0.68 95% confidence interval, 0.60-0.77 p < 0.001). Overall, 1,430 adult patients with uncomplicated acute appendicitis underwent either nonoperative (n = 727) or operative management (n = 703). RESULTS: Five RCTs were included in this review. Quality assessment of included RCTs was performed using the modified Jadad scale. The random-effects model (DerSimonian-Laird) was used to calculate pooled effect estimates when substantial heterogeneity was encountered otherwise, the fixed-effects (Mantel-Haenszel) model was implemented. Data on the study design, interventions, participants, and outcomes were extracted by two independent reviewers. METHODS: A systematic literature search of the PubMed, Cochrane, and Scopus databases was performed with respect to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement (end-of-search date: January 29, 2017). Retrieved October 9, 2021.BACKGROUND: Acute appendicitis continues to constitute a diagnostic and therapeutic challenge. ^ Stacey Harris-Papaioannou (August 19, 2021)."Mickey Rourke Finishes Filming "Man of God" in Greece". ^ Joanna Kalafatis (September 18, 2020)."Mickey Rourke wraps Greece shoot on 'Man Of God' (exclusive)". "How producers on Pure Flix sales title 'Man Of God' started production in Greece (exclusive)". "Mickey Rourke Joins Religious Drama 'Man of God' ". "Pinnacle Peak sells EFM title 'Walking With Herb', producing fourth 'God's Not Dead' film (exclusive)". " 'Man of God' film depicting life of St Nektarios to hit the big screen". " 'Man of God' wins audience award at world premiere". The film's opening four consecutive weeks sold 241,014 tickets in Greece. It was then released in theaters on August 26, 2021. The film made its world premiere on Apat the Moscow International Film Festival, where it won the Audience Award. Principal photography wrapped in Greece in September 2020. Onoufrios Dovletis as Villager (credit only).Nikitas Tsakiroglou as Patriarch Sophronius IV of Alexandria.Yannis Anastasakis as Metropolitan Theoklitos.Alexandros Mylonas as Metropolitan Meletius.Constantin Symsiris as Prosecutor clerk.In this exquisitely made film, relive Nectarios' inspiring devotion and perseverance as, despite the efforts of the religious establishment to discredit him and dismantle his good works over decades, he embraced humility and inspired thousands to become one of Greece's most renowned saints. In contrast to his religious superiors – the bishops and patriarchs mesmerized by worldly honors and power – Nectarios cared for the poor taught peasant girls to read and write inspired by example young men to enter the priesthood and wrote books and delivered sermons that uplifted nations of believers. A priest of the common people, his humility annoyed the prideful orthodox clergy of the day. Man of God brings to life the incredible true story of Saint Nectarios of Aegina, Greece. Man of God ( Greek: Ο Άνθρωπος του Θεού) is a 2021 English-language Greek biographical drama film written and directed by Yelena Popovic and starring Aris Servetalis as Nectarios of Aegina and also starring Mickey Rourke and Alexander Petrov.
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